Assume 2/5 assume 100bb stacks... we assume no passive stations behind but more aware players who might be aggressive.
Let's say you have been raising hand after hand preflop about 3-4 times in a row and getting folds preflop or on the flop. Now you get a hand like AJ that you should raise in the position you are in. But the players behind you are getting sick of your raising. Personally I find after I raise 2-3x in a row I get played back at by 3bs, floating, slowplaying big hands etc.
How does this affect how you play your AJ? Your opponents now have position and will play aggressive and unpredictable